Polyclonal Antibody to IkB- Alpha (Phospho-Tyr42) Antibody, Rabbit
Biozol Catalog Number:
ABI-35-1155
Supplier Catalog Number:
35-1155
Alternative Catalog Number:
ABI-35-1155-100UL
Manufacturer:
Abeomics
Host:
Rabbit
Category:
Antikörper
Application:
IHC, WB
Species Reactivity:
Human, Mouse
Immunogen:
Peptide sequence around phosphorylation site of tyrosine 42 (E-E-Y(p)-E-Q) derived from Human IkB-a
Alternative Names:
IKBA, MAD-3, NF-KBI, NF-KBIA
Inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL dimers in the cytoplasm through masking of their nuclear localization signals. On cellular stimulation by immune and proinflammatory responses, becomes phosphorylated promoting ubiquitination and degradation, enabling the dimeric RELA to tranlocate to the nucleus and activate transcription.
