Polyclonal Antibody to PKR (Phospho-Thr446), Rabbit
Artikelnummer:
ABI-35-1256-50
Hersteller Artikelnummer:
35-1256-50
Alternativnummer:
ABI-35-1256-50-50UL
Hersteller:
Abeomics
Wirt:
Rabbit
Kategorie:
Antikörper
Applikation:
IF, IHC, WB
Spezies Reaktivität:
Human
Immunogen:
Peptide sequence around phosphorylation site of threonine 446 (K-R-T(p)-R-S) derived from Human PKR.
Alternative Synonym:
ADRB2|| E2AK2|| EIF2AK2|| EIF2aK|| PRKR
Following activation by double-stranded RNA in the presence of ATP, the kinase becomes autophosphorylated and can catalyze the phosphorylation of the translation initiation factor EIF2S1, which leads to an inhibition of the initiation of protein synthesis. Double-stranded RNA is generated during the course of a viral infection. Abujiang Pataer, et,al. (2002) Cancer Res, 62: 2239. K. D. Ryman, et,al. (2005) J. Virol, 79: 1487 - 1499. Susana Guerra, et,al. (2006) J. Biol. Chem, 281: 18734 - 18745.
