Polyclonal Antibody to PKR (Phospho-Thr446), Rabbit
Biozol Catalog Number:
ABI-35-1256-50
Supplier Catalog Number:
35-1256-50
Alternative Catalog Number:
ABI-35-1256-50-50UL
Manufacturer:
Abeomics
Host:
Rabbit
Category:
Antikörper
Application:
IF, IHC, WB
Species Reactivity:
Human
Immunogen:
Peptide sequence around phosphorylation site of threonine 446 (K-R-T(p)-R-S) derived from Human PKR.
Alternative Names:
ADRB2|| E2AK2|| EIF2AK2|| EIF2aK|| PRKR
Following activation by double-stranded RNA in the presence of ATP, the kinase becomes autophosphorylated and can catalyze the phosphorylation of the translation initiation factor EIF2S1, which leads to an inhibition of the initiation of protein synthesis. Double-stranded RNA is generated during the course of a viral infection. Abujiang Pataer, et,al. (2002) Cancer Res, 62: 2239. K. D. Ryman, et,al. (2005) J. Virol, 79: 1487 - 1499. Susana Guerra, et,al. (2006) J. Biol. Chem, 281: 18734 - 18745.
