Mertansine (DM1) is a tubulin inhibitor that binds to the ends of microtubules and inhibits microtubule dynamics. DM1(Mertansine) has antitumor activity and functions as a regulator of tubulin. It is an alphaamino acid ester, a carbamate, an epoxide, an organic heterocyclic tetracyclic compound, an organochlorine compound, a mercaptan, and a maydenin alkaloid. DM1, derived from Mydenin, is a cytotoxic component of antibodydrug conjugations that produce antibodydrug conjugations via a sulfhydryl group splice with SPP (nsuccinimide 4 (2pyridyl dithio)) or SMCC (4 (3mercapto2, 5dioxy1 pyrrolidyl) cyclohexanic acid) splice. - Antikörper
Tag:
Mouse IgG1 | Mouse Kappa
Puffer:
PBS, pH7.4
Formulierung:
Powder
Target-Kategorie:
DM-1
Immobilized Trastuzumab-DM1 (T-DM1) at 2 µg/mL (100 µL/well) can bind HRP conjugated Monoclonal Anti-DM-1&DM-4 Antibody,Mouse IgG1 (Cat. No. DM1-PLY73) with a linear range of 0.24-15.63 ng/mL (QC tested).
Immobilized Human Her2, His Tag (Cat. No. HE2-H5225) at 1 µg/mL, add Trastuzumab-DM1 in the 100% Human Serum and then add HRP conjugated Monoclonal Anti-DM-1&DM-4 Antibody,Mouse IgG1 (Cat. No. DM1-PLY73) at 0.5 µg/mL (QC tested).
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