Monoclonal Anti-Duocarmycin Antibody, Rabbit IgG (M1E06), Unconjugated, Human

Produktübersicht

• Artikelname: Monoclonal Anti-Duocarmycin Antibody, Rabbit IgG (M1E06), Unconjugated, Human
• Artikelnummer: ABS-DUN-MY2287-100UG
• Hersteller Artikelnummer: DUN-MY2287-100ug
• Alternativnummer: ABS-DUN-MY2287-100UG
• Hersteller: AcroBiosystems
• Wirt: Human
• Kategorie: Antikörper
• Spezies Reaktivität: Rabbit
• Konjugation: Unconjugated

Produktbeschreibung

Duocarmycin, a DNA minor groovebinding alkylating agent, acts as a payload in antibodydrug conjugates (ADCs) by selectively targeting ATrich regions of DNA. It forms covalent bonds with the N3 position of adenine, inducing strand breaks and apoptosis through Sphase cell cycle arrest . This mechanism bypasses multidrug resistance pathways, making it potent against aggressive tumors. - Antikörper

Produkteigenschaften

• Tag: Rabbit IgG | Rabbit Kappa
• Puffer: PBS, pH7.4
• Formulierung: Powder
• Target-Kategorie: Duocarmycin

Bilder

Serial dilutions of Duocarmycin were added into BSA-Duocarmycin: Monoclonal Anti-Duocarmycin Antibody, Rabbit IgG (M1E06) (Cat. No. DUN-MY2287) binding reactions. The half maximal inhibitory concentration (IC50) is 0.10 µg/mL (QC tested).