Monoclonal Anti-Duocarmycin Antibody, Rabbit IgG (M1E06), Unconjugated, Human

Product Overview

• Article Name: Monoclonal Anti-Duocarmycin Antibody, Rabbit IgG (M1E06), Unconjugated, Human
• Biozol Catalog Number: ABS-DUN-MY2287-100UG
• Supplier Catalog Number: DUN-MY2287-100ug
• Alternative Catalog Number: ABS-DUN-MY2287-100UG
• Manufacturer: AcroBiosystems
• Host: Human
• Category: Antikörper
• Species Reactivity: Rabbit
• Conjugation: Unconjugated

Product Description

Duocarmycin, a DNA minor groovebinding alkylating agent, acts as a payload in antibodydrug conjugates (ADCs) by selectively targeting ATrich regions of DNA. It forms covalent bonds with the N3 position of adenine, inducing strand breaks and apoptosis through Sphase cell cycle arrest . This mechanism bypasses multidrug resistance pathways, making it potent against aggressive tumors. - Antikörper

Product Properties

• Tag: Rabbit IgG | Rabbit Kappa
• Buffer: PBS, pH7.4
• Form: Powder
• Target: Duocarmycin

Images

Serial dilutions of Duocarmycin were added into BSA-Duocarmycin: Monoclonal Anti-Duocarmycin Antibody, Rabbit IgG (M1E06) (Cat. No. DUN-MY2287) binding reactions. The half maximal inhibitory concentration (IC50) is 0.10 µg/mL (QC tested).