Human FoxP3 Protein, His Tag, Unconjugated, E. coli
Artikelnummer:
ABS-FO3-H5243-100UG
Hersteller Artikelnummer:
FO3-H5243-100ug
Alternativnummer:
ABS-FO3-H5243-100UG
Hersteller:
AcroBiosystems
Wirt:
E. coli
Kategorie:
Proteine/Peptide
Spezies Reaktivität:
Human
Konjugation:
Unconjugated
FOXP3 is a transcriptional regulator which is crucial for the development and inhibitory function of regulatory Tcells (Treg). It plays an essential role in maintaining homeostasis of the immune system by allowing the acquisition of full suppressive function and stability of the Treg lineage, and by directly modulating the expansion and function of conventional Tcells. Can act either as a transcriptional repressor or a transcriptional activator depending on its interactions with other transcription factors, histone acetylases and deacetylases. The suppressive activity of Treg involves the coordinate activation of many genes, including CTLA4 and TNFRSF18 by FOXP3 along with repression of genes encoding cytokines such as interleukin2 (IL2) and interferongamma (IFNG). Defects in this gene are the cause of immunodeficiency polyendocrinopathy, enteropathy, Xlinked syndrome (IPEX), also known as Xlinked autoimmunityimmunodeficiency syndrome. - Proteine/Peptide
