Human FoxP3 Protein, His Tag, Unconjugated, E. coli
Biozol Catalog Number:
ABS-FO3-H5243-100UG
Supplier Catalog Number:
FO3-H5243-100ug
Alternative Catalog Number:
ABS-FO3-H5243-100UG
Manufacturer:
AcroBiosystems
Host:
E. coli
Category:
Proteine/Peptide
Species Reactivity:
Human
Conjugation:
Unconjugated
FOXP3 is a transcriptional regulator which is crucial for the development and inhibitory function of regulatory Tcells (Treg). It plays an essential role in maintaining homeostasis of the immune system by allowing the acquisition of full suppressive function and stability of the Treg lineage, and by directly modulating the expansion and function of conventional Tcells. Can act either as a transcriptional repressor or a transcriptional activator depending on its interactions with other transcription factors, histone acetylases and deacetylases. The suppressive activity of Treg involves the coordinate activation of many genes, including CTLA4 and TNFRSF18 by FOXP3 along with repression of genes encoding cytokines such as interleukin2 (IL2) and interferongamma (IFNG). Defects in this gene are the cause of immunodeficiency polyendocrinopathy, enteropathy, Xlinked syndrome (IPEX), also known as Xlinked autoimmunityimmunodeficiency syndrome. - Proteine/Peptide
