Biotinylated Rat Her2 / ErbB2 Protein, His,Avitag(TM) (MALS verified), Human

Produktübersicht

• Artikelname: Biotinylated Rat Her2 / ErbB2 Protein, His,Avitag(TM) (MALS verified), Human
• Artikelnummer: ABS-HE2-R82E3-200UG
• Hersteller Artikelnummer: HE2-R82E3-200ug
• Alternativnummer: ABS-HE2-R82E3-200UG
• Hersteller: AcroBiosystems
• Wirt: Human
• Kategorie: Proteine/Peptide
• Spezies Reaktivität: Rat
• Konjugation: Biotin

Produktbeschreibung

Human Epidermal Growth Factor Receptor 2 (HER2), also known as ErbB2, is a cell membranebound receptor tyrosine kinase of the EGFR/ErbB family, encoded by the ERBB2 gene. It is crucial for cell growth and differentiation signaling. Uniquely, HER2 is an orphan receptor lacking a direct ligand, but forms highly active heterodimers with other ligandbound ErbB family members, significantly amplifying oncogenic signals. Aberrant amplification or overexpression of the HER2/neu protooncogene is a key oncogenic driver. In breast cancer, approximately 2530% of patients exhibit HER2 overexpression, leading to a more aggressive disease phenotype with faster growth, increased metastasis, and often reduced chemotherapy sensitivity. This correlates with poorer prognosis and makes HER2 a critical prognostic, predictive biomarker, and a major therapeutic target. - Proteine/Peptide

Produkteigenschaften

• Molekulargewicht: 73.3 kDa
• Tag: C-10*His & C-Avi
• NCBI: 61863
• Puffer: PBS, pH7.4
• Reinheit: 95%
• Formulierung: Powder
• Target-Kategorie: Her2

Bilder

Biotinylated Rat Her2 Protein, His,Avitag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%.