Biotinylated Rat Her2 / ErbB2 Protein, His,Avitag(TM) (MALS verified), Human
Biozol Catalog Number:
ABS-HE2-R82E3-200UG
Supplier Catalog Number:
HE2-R82E3-200ug
Alternative Catalog Number:
ABS-HE2-R82E3-200UG
Manufacturer:
AcroBiosystems
Host:
Human
Category:
Proteine/Peptide
Species Reactivity:
Rat
Conjugation:
Biotin
Human Epidermal Growth Factor Receptor 2 (HER2), also known as ErbB2, is a cell membranebound receptor tyrosine kinase of the EGFR/ErbB family, encoded by the ERBB2 gene. It is crucial for cell growth and differentiation signaling. Uniquely, HER2 is an orphan receptor lacking a direct ligand, but forms highly active heterodimers with other ligandbound ErbB family members, significantly amplifying oncogenic signals. Aberrant amplification or overexpression of the HER2/neu protooncogene is a key oncogenic driver. In breast cancer, approximately 2530% of patients exhibit HER2 overexpression, leading to a more aggressive disease phenotype with faster growth, increased metastasis, and often reduced chemotherapy sensitivity. This correlates with poorer prognosis and makes HER2 a critical prognostic, predictive biomarker, and a major therapeutic target. - Proteine/Peptide
Biotinylated Rat Her2 Protein, His,Avitag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%.
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