Human PCSK9 Protein, His Tag (MALS verified), Unconjugated

Produktübersicht

• Artikelname: Human PCSK9 Protein, His Tag (MALS verified), Unconjugated
• Artikelnummer: ABS-PC9-H5223-1MG
• Hersteller Artikelnummer: PC9-H5223-1mg
• Alternativnummer: ABS-PC9-H5223-1MG
• Hersteller: AcroBiosystems
• Wirt: Human
• Kategorie: Proteine/Peptide
• Spezies Reaktivität: Human
• Konjugation: Unconjugated

Produktbeschreibung

Proprotein convertase subtilisin/kexin type 9 (PCSK9) is also known as NARC1 (neural apoptosis regulated convertase), is a newly identified subtilase belonging to the peptidase S8 subfamily. Mouse PCSK9 is synthesized as a soluble zymogen, and undergoes autocatalytic intramolecular processing in the endoplasmic reticulum, resulting in the cleavage of its propeptide that remains associated with the secreted active enzyme with a broad alkaline pH optimum. This protein plays a major regulatory role in cholesterol homeostasis. PCSK9 binds to the epidermal growth factorlike repeat A (EGFA) domain of the lowdensity lipoprotein receptor (LDLR), inducing LDLR degradation. PCSK9 may also have a role in the differentiation of cortical neurons. Mutations in this gene have been associated with a rare form of autosomal dominant familial hypercholesterolemia (HCHOLA3). - Proteine/Peptide

Produkteigenschaften

• Molekulargewicht: 13.8 kDa and 59.2 kDa
• Tag: C-10*His
• NCBI: 8
• Puffer: PBS, pH7.4
• Reinheit: 90%
• Formulierung: Powder
• Target-Kategorie: PCSK9

Bilder

Immobilized Human PCSK9, His Tag (Cat. No. PC9-H5223) at 5 µg/mL (100 µL/well) can bind Human LDL R, Fc Tag with a linear range of 10-156 ng/mL (QC tested).

Immobilized Human PCSK9, His Tag (Cat. No. PC9-H5223) at 2 µg/mL (100 µL/well) on an Nickel Coated plate can bind Human PCSK9 Mab (RN316), Human IgG1 with a linear range of 0.2-3 ng/mL (Routinely tested).

PC9-H5223-1mg

Human PCSK9, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 90%.