Human PCSK9 Protein, His Tag (MALS verified), Unconjugated

Product Overview

• Article Name: Human PCSK9 Protein, His Tag (MALS verified), Unconjugated
• Biozol Catalog Number: ABS-PC9-H5223-1MG
• Supplier Catalog Number: PC9-H5223-1mg
• Alternative Catalog Number: ABS-PC9-H5223-1MG
• Manufacturer: AcroBiosystems
• Host: Human
• Category: Proteine/Peptide
• Species Reactivity: Human
• Conjugation: Unconjugated

Product Description

Proprotein convertase subtilisin/kexin type 9 (PCSK9) is also known as NARC1 (neural apoptosis regulated convertase), is a newly identified subtilase belonging to the peptidase S8 subfamily. Mouse PCSK9 is synthesized as a soluble zymogen, and undergoes autocatalytic intramolecular processing in the endoplasmic reticulum, resulting in the cleavage of its propeptide that remains associated with the secreted active enzyme with a broad alkaline pH optimum. This protein plays a major regulatory role in cholesterol homeostasis. PCSK9 binds to the epidermal growth factorlike repeat A (EGFA) domain of the lowdensity lipoprotein receptor (LDLR), inducing LDLR degradation. PCSK9 may also have a role in the differentiation of cortical neurons. Mutations in this gene have been associated with a rare form of autosomal dominant familial hypercholesterolemia (HCHOLA3). - Proteine/Peptide

Product Properties

• Molecular Weight: 13.8 kDa and 59.2 kDa
• Tag: C-10*His
• NCBI: 8
• Buffer: PBS, pH7.4
• Purity: 90%
• Form: Powder
• Target: PCSK9

Images

Immobilized Human PCSK9, His Tag (Cat. No. PC9-H5223) at 5 µg/mL (100 µL/well) can bind Human LDL R, Fc Tag with a linear range of 10-156 ng/mL (QC tested).

Immobilized Human PCSK9, His Tag (Cat. No. PC9-H5223) at 2 µg/mL (100 µL/well) on an Nickel Coated plate can bind Human PCSK9 Mab (RN316), Human IgG1 with a linear range of 0.2-3 ng/mL (Routinely tested).

PC9-H5223-1mg

Human PCSK9, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 90%.