Human PRMT5 & MEP50 Protein, Flag,His Tag (MALS verified), Unconjugated, Insect 1 mg

Produktübersicht

• Artikelname: Human PRMT5 & MEP50 Protein, Flag,His Tag (MALS verified), Unconjugated, Insect 1 mg
• Artikelnummer: ABS-PR5-H55D3-1MG
• Hersteller Artikelnummer: PR5-H55D3-1mg
• Alternativnummer: ABS-PR5-H55D3-1MG
• Hersteller: AcroBiosystems
• Wirt: Insect
• Kategorie: Proteine/Peptide
• Spezies Reaktivität: Human
• Konjugation: Unconjugated

Produktbeschreibung

Protein arginine methyltransferase 5 (PRMT5) is a type II enzyme that catalyzes symmetric dimethylation of arginine residues on histone and nonhistone proteins. It forms a heterooctameric complex with its essential cofactor MEP50 (methylosome protein 50), which enhances its catalytic activity and substrate selectivity. The PRMT5-MEP50 complex regulates gene expression epigenetically, influences RNA splicing, and modulates signal transduction pathways. Aberrant PRMT5-MEP50 activity is linked to tumorigenesis, cardiovascular disorders, and neurodegeneration by driving dysregulated methylation patterns that favor cell proliferation and survival. - Proteine/Peptide

Produkteigenschaften

• Molekulargewicht: 74.4 kDa & 38.3 kDa
• Tag: N-Flag | N-10*His
• NCBI: 14744
• Puffer: 50 mM Tris, 500 mM NaCl, pH7.5
• Reinheit: 90%
• Formulierung: Liquid
• Target-Kategorie: PRMT5 & MEP50

Bilder

Human PRMT5 & MEP50 Protein, Flag,His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 90%.