Human PRMT5 & MEP50 Protein, Flag,His Tag (MALS verified), Unconjugated, Insect 1 mg

Product Overview

• Article Name: Human PRMT5 & MEP50 Protein, Flag,His Tag (MALS verified), Unconjugated, Insect 1 mg
• Biozol Catalog Number: ABS-PR5-H55D3-1MG
• Supplier Catalog Number: PR5-H55D3-1mg
• Alternative Catalog Number: ABS-PR5-H55D3-1MG
• Manufacturer: AcroBiosystems
• Host: Insect
• Category: Proteine/Peptide
• Species Reactivity: Human
• Conjugation: Unconjugated

Product Description

Protein arginine methyltransferase 5 (PRMT5) is a type II enzyme that catalyzes symmetric dimethylation of arginine residues on histone and nonhistone proteins. It forms a heterooctameric complex with its essential cofactor MEP50 (methylosome protein 50), which enhances its catalytic activity and substrate selectivity. The PRMT5-MEP50 complex regulates gene expression epigenetically, influences RNA splicing, and modulates signal transduction pathways. Aberrant PRMT5-MEP50 activity is linked to tumorigenesis, cardiovascular disorders, and neurodegeneration by driving dysregulated methylation patterns that favor cell proliferation and survival. - Proteine/Peptide

Product Properties

• Molecular Weight: 74.4 kDa & 38.3 kDa
• Tag: N-Flag | N-10*His
• NCBI: 14744
• Buffer: 50 mM Tris, 500 mM NaCl, pH7.5
• Purity: 90%
• Form: Liquid
• Target: PRMT5 & MEP50

Images

Human PRMT5 & MEP50 Protein, Flag,His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 90%.