Human R-Spondin 1 / RSPO1 Protein, His Tag, Unconjugated
Artikelnummer:
ABS-RS1-H4221-1MG
Hersteller Artikelnummer:
RS1-H4221-1mg
Alternativnummer:
ABS-RS1-H4221-1MG
Hersteller:
AcroBiosystems
Wirt:
Human
Kategorie:
Proteine/Peptide
Spezies Reaktivität:
Human
Konjugation:
Unconjugated
Rspondin1 is also known as Roof platespecific Spondin 1 (RSPO1) and cysteinerich and single thrombospondin domain containing protein 3 (Cristin 3), which is a secreted protein which belongs to the RSpondin family and encodes a secreted activator protein with two cysteinrich, furinlike domains and one thrombospondin type 1 domain. All Rspondins regulate Wnt/betacatenin signaling, but have distinct expression patterns. Like other RSpondins, RSpondin1 contains two adjacent cysteinerich furinlike domains (aa 34135) with one potential Nglycosylation site, followed by a thrombospondin (TSP1) motif (aa 147207) and a region rich in basic residues (aa 211263). Only the furinlike domains are needed for betacatenin stabilization. A putative nuclear localization signal at the Cterminus may allow some expression in the nucleus. - Proteine/Peptide
