Anti-Profilin (Tyr-129), Phosphospecific Antibody, Rabbit, Polyclonal

Produktübersicht

• Artikelname: Anti-Profilin (Tyr-129), Phosphospecific Antibody, Rabbit, Polyclonal
• Artikelnummer: ABT-AN1923
• Hersteller Artikelnummer: AN1923
• Alternativnummer: ABT-AN1923-100UL
• Hersteller: Abcepta
• Wirt: Rabbit
• Kategorie: Antikörper
• Alternative Synonym: Epididymis Li184a Profilin PFN1 PFN2

Produktbeschreibung

Profilins are small actin-binding proteins that have functions in cell motility, cytokinesis, gene transcription, endocytosis and neuronal plasticity. Four profilin isoforms have been identified in mammals. Profilin-1 (PFN1) and profilin-2a (PFN2a) isoforms are highly conserved in structure, but PFN1 is ubiquitously expressed while PFN2a is preferentially enriched in brain. In addition, there are two testis-specific profilins, PFN3 and PFN4, that significantly differ in primary sequence and function compared to PFN1 and PFN2a. Profilin is phosphorylated at both tyrosine and serine residues in vivo. Tyr-129 is phosphorylated in response to VEGF-A stimulation, and this promotes profilin actin binding and polymerization. Tyr-129 phosphorylation may be important for angiogenesis induced by injuries. Ser-138 is phosphorylated by ROCK and dephosphorylated by PP1. This serine phosphorylation inhibits G-actin binding, as well as decreases profilins aggregation suppressor activity by inhibiting binding to huntingtin. Thus, Tyr-129 phosphorylation may activate while Ser-138 phosphorylation may inhibit profilin activity.

Produkteigenschaften

• Klonalität: Polyclonal
• Molekulargewicht: 15054
• NCBI: 5216
• UniProt: P07737