Anti-Profilin (Tyr-129), Phosphospecific Antibody, Rabbit, Polyclonal
Catalog Number:
ABT-AN1923
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| Article Name: | Anti-Profilin (Tyr-129), Phosphospecific Antibody, Rabbit, Polyclonal |
| Biozol Catalog Number: | ABT-AN1923 |
| Supplier Catalog Number: | AN1923 |
| Alternative Catalog Number: | ABT-AN1923-100UL |
| Manufacturer: | Abcepta |
| Host: | Rabbit |
| Category: | Antikörper |
| Alternative Names: | Epididymis Li184a Profilin PFN1 PFN2 |
| Profilins are small actin-binding proteins that have functions in cell motility, cytokinesis, gene transcription, endocytosis and neuronal plasticity. Four profilin isoforms have been identified in mammals. Profilin-1 (PFN1) and profilin-2a (PFN2a) isoforms are highly conserved in structure, but PFN1 is ubiquitously expressed while PFN2a is preferentially enriched in brain. In addition, there are two testis-specific profilins, PFN3 and PFN4, that significantly differ in primary sequence and function compared to PFN1 and PFN2a. Profilin is phosphorylated at both tyrosine and serine residues in vivo. Tyr-129 is phosphorylated in response to VEGF-A stimulation, and this promotes profilin actin binding and polymerization. Tyr-129 phosphorylation may be important for angiogenesis induced by injuries. Ser-138 is phosphorylated by ROCK and dephosphorylated by PP1. This serine phosphorylation inhibits G-actin binding, as well as decreases profilins aggregation suppressor activity by inhibiting binding to huntingtin. Thus, Tyr-129 phosphorylation may activate while Ser-138 phosphorylation may inhibit profilin activity. |
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