Anti-SHP2 (N-terminal region) Antibody, IgG1, Clone: [M163], Mouse, Monoclonal

Produktübersicht

• Artikelname: Anti-SHP2 (N-terminal region) Antibody, IgG1, Clone: [M163], Mouse, Monoclonal
• Artikelnummer: ABT-AN1956
• Hersteller Artikelnummer: AN1956
• Alternativnummer: ABT-AN1956-100UL
• Hersteller: Abcepta
• Wirt: Mouse
• Kategorie: Antikörper
• Alternative Synonym: PTP1D, SHPTP2, Syp

Produktbeschreibung

SHP2 (PTP1D, SH-PTP2, or Syp) is a widely expressed protein-tyrosine phosphatase (PTP) that maintains phosphotyrosine homeostasis during growth factor, cytokine, hormone and antigen receptor signaling. This phosphatase contains two N-terminal SH2 domains and a C-terminal phosphatase domain. SHP2 associates with EGF and PDGF growth factor receptors and is activated after stimulation of these receptors. Activation of SHP-2 and its association with Gab1 is critical for sustained ERK activation downstream of both growth factor and cytokine receptors. In addition to its role in Gab1-mediated Erk activation, SHP-2 attenuates EGF-dependent PI3 kinase activation by dephosphorylating Gab1 p85 binding sites. Thus, SHP2 is critical for maintaining phosphotyrosine homeostasis in many cell signaling pathways

Produkteigenschaften

• Klonalität: Monoclonal
• Klon-Bezeichnung: [M163]
• Molekulargewicht: 68011
• Isotyp: IgG1
• NCBI: 5781
• UniProt: Q06124