Anti-SHP2 (N-terminal region) Antibody, IgG1, Clone: [M163], Mouse, Monoclonal
Catalog Number:
ABT-AN1956
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| Article Name: | Anti-SHP2 (N-terminal region) Antibody, IgG1, Clone: [M163], Mouse, Monoclonal |
| Biozol Catalog Number: | ABT-AN1956 |
| Supplier Catalog Number: | AN1956 |
| Alternative Catalog Number: | ABT-AN1956-100UL |
| Manufacturer: | Abcepta |
| Host: | Mouse |
| Category: | Antikörper |
| Alternative Names: | PTP1D, SHPTP2, Syp |
| SHP2 (PTP1D, SH-PTP2, or Syp) is a widely expressed protein-tyrosine phosphatase (PTP) that maintains phosphotyrosine homeostasis during growth factor, cytokine, hormone and antigen receptor signaling. This phosphatase contains two N-terminal SH2 domains and a C-terminal phosphatase domain. SHP2 associates with EGF and PDGF growth factor receptors and is activated after stimulation of these receptors. Activation of SHP-2 and its association with Gab1 is critical for sustained ERK activation downstream of both growth factor and cytokine receptors. In addition to its role in Gab1-mediated Erk activation, SHP-2 attenuates EGF-dependent PI3 kinase activation by dephosphorylating Gab1 p85 binding sites. Thus, SHP2 is critical for maintaining phosphotyrosine homeostasis in many cell signaling pathways |
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