Anti-SMAD7 (N-terminal region) Antibody, Rabbit, Polyclonal

Produktübersicht

• Artikelname: Anti-SMAD7 (N-terminal region) Antibody, Rabbit, Polyclonal
• Artikelnummer: ABT-AN1959
• Hersteller Artikelnummer: AN1959
• Alternativnummer: ABT-AN1959-100UL
• Hersteller: Abcepta
• Wirt: Rabbit
• Kategorie: Antikörper
• Applikation: WB
• Spezies Reaktivität: Drosophila
• Alternative Synonym: MADH7, MADH8, MAD7

Produktbeschreibung

SMADs are members of the MAD-related family of molecules. MAD-related proteins are a family of intracellular proteins that are essential components in the signaling pathways of the serine/threonine kinase receptors of the transforming growth factor beta superfamily. SMADs can be divided into receptor-regulated SMADs (R-SMADs: SMAD1, 2, 3. 5 and 8), common-mediator SMAD (co-SMAD: SMAD4), and inhibitory SMADs (I-SMADs: SMAD6 and 7). Briefly, activated type I receptors associate with specific R-Smads and phosphorylate them on a conserved SSXS motif at the carboxy-terminus of the proteins. The phosphorylated R-Smad dissociates from the receptor and forms a heteromeric complex with the co-Smad, Smad4, and together the complex moves to the nucleus. Once in the nucleus, Smads can target a variety of DNA binding proteins to regulate transcriptional responses.

Produkteigenschaften

• Klonalität: Polyclonal
• Molekulargewicht: 46426
• NCBI: 4092
• UniProt: O15105