Anti-SMAD7 (N-terminal region) Antibody, Rabbit, Polyclonal
Catalog Number:
ABT-AN1959
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| Article Name: | Anti-SMAD7 (N-terminal region) Antibody, Rabbit, Polyclonal |
| Biozol Catalog Number: | ABT-AN1959 |
| Supplier Catalog Number: | AN1959 |
| Alternative Catalog Number: | ABT-AN1959-100UL |
| Manufacturer: | Abcepta |
| Host: | Rabbit |
| Category: | Antikörper |
| Application: | WB |
| Species Reactivity: | Drosophila |
| Alternative Names: | MADH7, MADH8, MAD7 |
| SMADs are members of the MAD-related family of molecules. MAD-related proteins are a family of intracellular proteins that are essential components in the signaling pathways of the serine/threonine kinase receptors of the transforming growth factor beta superfamily. SMADs can be divided into receptor-regulated SMADs (R-SMADs: SMAD1, 2, 3. 5 and 8), common-mediator SMAD (co-SMAD: SMAD4), and inhibitory SMADs (I-SMADs: SMAD6 and 7). Briefly, activated type I receptors associate with specific R-Smads and phosphorylate them on a conserved SSXS motif at the carboxy-terminus of the proteins. The phosphorylated R-Smad dissociates from the receptor and forms a heteromeric complex with the co-Smad, Smad4, and together the complex moves to the nucleus. Once in the nucleus, Smads can target a variety of DNA binding proteins to regulate transcriptional responses. |
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