MYD88 Antibody, Rabbit, Polyclonal

Produktübersicht

• Artikelname: MYD88 Antibody, Rabbit, Polyclonal
• Artikelnummer: ABT-AP51372
• Hersteller Artikelnummer: AP51372
• Alternativnummer: ABT-AP51372-100UL
• Hersteller: Abcepta
• Wirt: Rabbit
• Kategorie: Antikörper
• Applikation: ELISA, ICC, WB
• Spezies Reaktivität: Human, Mouse, Rat
• Alternative Synonym: Myeloid differentiation primary response protein MyD88, MYD88

Produktbeschreibung

Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes. MyD88-mediated signaling in intestinal epithelial cells is crucial for maintenance of gut homeostasis and controls the expression of the antimicrobial lectin REG3G in the small intestine.

Produkteigenschaften

• Klonalität: Polyclonal
• NCBI: 4615
• UniProt: Q99836