8-CPT-2Me-cAMP sodium is a selective activator of exchange proteins activated by cAMP (Epac), the cAMP sensitive guanine nucleotide exchange factors (GEFs) for the small GTPases Rap1 and Rap2. 8-CPT-2Me-cAMP sodium activates Epac1 (EC50 = 2.2 µM), but not PKA (EC50> 10 µM). 8-CPT-2Me-cAMP sodium stimulates Epac-mediated Ca2+ release in pancreatic beta-cells in vitro.
Molekulargewicht:
507.82
Reinheit:
99.0%
CAS Nummer:
[634207-53-7]
Formel:
C17H16ClN5NaO6PS
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