JNJ-28583113 is a brain-permeable TRPM2 antagonist and blocks phosphorylation of GSK3alpha and beta subunits by inhibiting TRPM2. In addition, JNJ-28583113 inhibits cytokine release from microglia in response to pro-inflammatory stimuli. It has the function of protecting cells from oxidative stress-induced cell death.
Molekulargewicht:
366.38
Reinheit:
>98.0%
CAS Nummer:
[2765255-93-2]
Formel:
C19H21F3N2O2
Target-Kategorie:
TRP Channel
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