Rademikibart is a human IgG4 monoclonal antibody that targets IL-4 Ralpha to block inflammatory signaling induced by IL-4 and IL-13, two important cytokines that drive allergic inflammation, and binds to the human IL-4Ralpha epitope with a KD of 20.7 pM. Rademikibart does not bind to IL-4Ralpha from other species. Rademikibart does not bind to IL-4Ralpha of other species.Rademikibart inhibits IL-4 and IL-13-mediated STAT6 signaling, TF-1 cell proliferation, and TARC production in PBMC, and can be used in studies related to moderate-to-severe Th2 inflammatory diseases.
CAS Nummer:
[2648260-80-2]
Target-Kategorie:
IL Receptor/Related
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