CCR5 Antibody - middle region

Produktübersicht

• Artikelname: CCR5 Antibody - middle region
• Artikelnummer: ASB-ARP30788_P050
• Hersteller Artikelnummer: ARP30788_P050
• Alternativnummer: ASB-ARP30788_P050-25UL,ASB-ARP30788_P050-100UL
• Hersteller: Aviva
• Wirt: Rabbit
• Kategorie: Proteine/Peptide
• Applikation: WB
• Spezies Reaktivität: Bovine, Human, Porcine
• Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human CCR5
• Alternative Synonym: CKR5, CCR-5, CD195, CKR-5, CCCKR5, CMKBR5, IDDM22, CC-CKR-5

Produktbeschreibung

CCR5 is a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. The protein is expressed by T cells and macrophages, and is known to be an important co-receptor for macrophage-tropic virus, including HIV, to enter host cells. Defective alleles of this gene have been associated with the HIV infection resistance. The ligands of this receptor include monocyte chemoattractant protein 2 (MCP-2), macrophage inflammatory protein 1 alpha (MIP-1 alpha), macrophage inflammatory protein 1 beta (MIP-1 beta) and regulated on activation normal T expressed and secreted protein (RANTES). Expression of this protein was also detected in a promyeloblastic cell line, suggesting that CCR5 may play a role in granulocyte lineage proliferation and differentiation. This gene is located at the chemokine receptor gene cluster region. Two transcript variants encoding the same protein have been found for this gene.This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. This protein is expressed by T cells and macrophages, and is known to be an important co-receptor for macrophage-tropic virus, including HIV, to enter host cells. Defective alleles of this gene have been associated with the HIV infection resistance. The ligands of this receptor include monocyte chemoattractant protein 2 (MCP-2), macrophage inflammatory protein 1 alpha (MIP-1 alpha), macrophage inflammatory protein 1 beta (MIP-1 beta) and regulated on activation normal T expressed and secreted protein (RANTES). Expression of this gene was also detected in a promyeloblastic cell line, suggesting that this protein may play a role in granulocyte lineage proliferation and differentiation. This gene is located at the chemokine receptor gene cluster region. Two transcript variants encoding the same protein have been found for this gene.

Produkteigenschaften

• Klonalität: Polyclonal
• Konzentration: 0.5 mg/ml
• Molekulargewicht: 41kDa
• NCBI: 1234
• UniProt: P51681
• Formulierung: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

Bilder

Host: Rabbit
Target Name: CCR5
Sample Tissue: Human HepG2 Whole Cell
Antibody Dilution: 1ug/ml

Host: Rabbit
Target Name: CCR5
Sample Tissue: Human Jurkat Whole Cell
Antibody Dilution: 1ug/ml

WB Suggested Anti-CCR5 Antibody Titration: 0.2-1 ug/ml
ELISA Titer: 1:312500
Positive Control: Human heart

Host: Rabbit
Target Name: CCR5
Sample Type: Human Fetal Liver
Antibody Dilution: 1.0ug/ml

CCR5 antibody - middle region (ARP30788_P050) in HepG2 Whole Cell using Western Blot