E2F3 Antibody - C-terminal region

Produktübersicht

• Artikelname: E2F3 Antibody - C-terminal region
• Artikelnummer: ASB-ARP38089_P050
• Hersteller Artikelnummer: ARP38089_P050
• Alternativnummer: ASB-ARP38089_P050-25UL,ASB-ARP38089_P050-100UL
• Hersteller: Aviva
• Wirt: Rabbit
• Kategorie: Proteine/Peptide
• Applikation: WB
• Spezies Reaktivität: Bovine, Canine, Equine, Guinea pig, Human, Mouse, Rabbit, Rat
• Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human E2F3
• Alternative Synonym: E2F-3

Produktbeschreibung

E2F3 is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F1 and E2F2, have an additional cyclin binding domain. E2F3 binds specifically to retinoblastoma protein pRB in a cell-cycle dependent manner.

Produkteigenschaften

• Klonalität: Polyclonal
• Konzentration: 0.5 mg/ml
• Molekulargewicht: 49 kDa
• NCBI: 1871
• UniProt: Q68DT0
• Formulierung: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

Bilder

Host: Rabbit
Target Name: E2F3
Sample Tissue: Human Lung Tumor
Antibody Dilution: 1ug/ml

25 ug of the indicated Human whole cell or tissue extracts was loaded onto a 6-18% SDS-PAGE gel. 3 ug/mL of the antibody was used in this experiment. The peptide sequence is also present in isoforms of 42 kDa and 37 kDa.

Host: Rabbit
Target Name: E2F3
Sample Tissue: Human OVCAR-3 Whole Cell
Antibody Dilution: 1ug/ml

Host: Rabbit
Target Name: E2F3
Sample Tissue: Human Ovary Tumor
Antibody Dilution: 1.0ug/ml

Host: Rabbit
Target Name: E2F3
Sample Tissue: Human OVCAR-3 Whole Cell
Antibody Dilution: 0.5ug/ml

WB Suggested Anti-E2F3 Antibody Titration: 0.2-1 ug/ml
ELISA Titer: 1:62500
Positive Control: Human Thymus

Host: Mouse
Target Name: E2F3
Sample Tissue: Mouse Small Intestine
Antibody Dilution: 1ug/ml

E2F3 antibody - C-terminal region (ARP38089_P050) in Lung Tumor using Western Blot