Bovine, Canine, Guinea pig, Human, Mouse, Porcine, Rat
Immunogen:
The immunogen is a synthetic peptide directed towards the N terminal region of human NR1I3
Alternative Synonym:
CAR, CAR1, MB67
NR1I3 mediates the induction of transcription of cytochrome P450 (CYP) genes by phenobarbital (PB) and PB-type inducers. NR1I3 activation induces hepatic expression of detoxification enzymes and transporters and increases liver size. NR1I3 can also regulate both liver homeostasis and tumorigenesis in response to xenobiotic stresses.