IDH1 Antibody - C-terminal region

Produktübersicht

• Artikelname: IDH1 Antibody - C-terminal region
• Artikelnummer: ASB-ARP54788_P050
• Hersteller Artikelnummer: ARP54788_P050
• Alternativnummer: ASB-ARP54788_P050-25UL,ASB-ARP54788_P050-100UL
• Hersteller: Aviva
• Wirt: Rabbit
• Kategorie: Proteine/Peptide
• Applikation: IHC, WB
• Spezies Reaktivität: Bovine, Canine, Equine, Guinea pig, Human, Mouse, Rabbit, Rat, Sheep
• Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human IDH1
• Alternative Synonym: IDH, IDP, IDCD, IDPC, PICD, HEL-216, HEL-S-26

Produktbeschreibung

Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+).The protein encoded by this gene is the NADP(+)-dependent isocitrate dehydrogenase found in the cytoplasm and peroxisomes. It contains the PTS-1 peroxisomal targeting signal sequence. The presence of this enzyme in peroxisomes suggests roles in the regeneration of NADPH for intraperoxisomal reductions, such as the conversion of 2, 4-dienoyl-CoAs to 3-enoyl-CoAs, as well as in peroxisomal reactions that consume 2-oxoglutarate, namely the alpha-hydroxylation of phytanic acid. The cytoplasmic enzyme serves a significant role in cytoplasmic NADPH production.Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. Each NADP(+)-dependent isozyme is a homodimer. The protein encoded by this gene is the NADP(+)-dependent isocitrate dehydrogenase found in the cytoplasm and peroxisomes. It contains the PTS-1 peroxisomal targeting signal sequence. The presence of this enzyme in peroxisomes suggests roles in the regeneration of NADPH for intraperoxisomal reductions, such as the conversion of 2, 4-dienoyl-CoAs to 3-enoyl-CoAs, as well as in peroxisomal reactions that consume 2-oxoglutarate, namely the alpha-hydroxylation of phytanic acid. The cytoplasmic enzyme serves a significant role in cytoplasmic NADPH production. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.

Produkteigenschaften

• Klonalität: Polyclonal
• Konzentration: 0.5 mg/ml
• Molekulargewicht: 47kDa
• NCBI: 3417
• UniProt: O75874
• Formulierung: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

Bilder

Human Testis

Human Testis

WB Suggested Anti-IDH1 Antibody Titration: 1 ug/ml
Positive Control: Fetal liver cell lysate

Host: Rabbit
Target Name: IDH1
Sample Type: Human HepG2
Antibody Dilution: 1.0ug/mlIDH1 is supported by BioGPS gene expression data to be expressed in HepG2

Host: Rabbit
Target Name: IDH1
Sample Type: Human MCF7
Antibody Dilution: 1.0ug/mlIDH1 is supported by BioGPS gene expression data to be expressed in MCF7

Host: Rat
Target Name: IDH1
Sample Tissue: Rat Liver
Antibody Dilution: 1ug/ml

IDH1 antibody - C-terminal region (ARP54788_P050) in Human Fetal liver using Western Blot