IDH1 Antibody - C-terminal region
Catalog Number:
ASB-ARP54788_P050
- Images (7)
| Article Name: | IDH1 Antibody - C-terminal region |
| Biozol Catalog Number: | ASB-ARP54788_P050 |
| Supplier Catalog Number: | ARP54788_P050 |
| Alternative Catalog Number: | ASB-ARP54788_P050-25UL,ASB-ARP54788_P050-100UL |
| Manufacturer: | Aviva |
| Host: | Rabbit |
| Category: | Proteine/Peptide |
| Application: | IHC, WB |
| Species Reactivity: | Bovine, Canine, Equine, Guinea pig, Human, Mouse, Rabbit, Rat, Sheep |
| Immunogen: | The immunogen is a synthetic peptide directed towards the C terminal region of human IDH1 |
| Alternative Names: | IDH, IDP, IDCD, IDPC, PICD, HEL-216, HEL-S-26 |
| Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+).The protein encoded by this gene is the NADP(+)-dependent isocitrate dehydrogenase found in the cytoplasm and peroxisomes. It contains the PTS-1 peroxisomal targeting signal sequence. The presence of this enzyme in peroxisomes suggests roles in the regeneration of NADPH for intraperoxisomal reductions, such as the conversion of 2, 4-dienoyl-CoAs to 3-enoyl-CoAs, as well as in peroxisomal reactions that consume 2-oxoglutarate, namely the alpha-hydroxylation of phytanic acid. The cytoplasmic enzyme serves a significant role in cytoplasmic NADPH production.Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. Each NADP(+)-dependent isozyme is a homodimer. The protein encoded by this gene is the NADP(+)-dependent isocitrate dehydrogenase found in the cytoplasm and peroxisomes. It contains the PTS-1 peroxisomal targeting signal sequence. The presence of this enzyme in peroxisomes suggests roles in the regeneration of NADPH for intraperoxisomal reductions, such as the conversion of 2, 4-dienoyl-CoAs to 3-enoyl-CoAs, as well as in peroxisomal reactions that consume 2-oxoglutarate, namely the alpha-hydroxylation of phytanic acid. The cytoplasmic enzyme serves a significant role in cytoplasmic NADPH production. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications. |
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Human Testis |
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Human Testis |
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WB Suggested Anti-IDH1 Antibody Titration: 1 ug/ml Positive Control: Fetal liver cell lysate |
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Host: Rabbit Target Name: IDH1 Sample Type: Human HepG2 Antibody Dilution: 1.0ug/mlIDH1 is supported by BioGPS gene expression data to be expressed in HepG2 |
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Host: Rabbit Target Name: IDH1 Sample Type: Human MCF7 Antibody Dilution: 1.0ug/mlIDH1 is supported by BioGPS gene expression data to be expressed in MCF7 |
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Host: Rat Target Name: IDH1 Sample Tissue: Rat Liver Antibody Dilution: 1ug/ml |
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IDH1 antibody - C-terminal region (ARP54788_P050) in Human Fetal liver using Western Blot |
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