SH2D1A Antibody - C-terminal region, Rabbit, Polyclonal
Artikelnummer:
ASB-ARP60359_P050
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| Artikelname: | SH2D1A Antibody - C-terminal region, Rabbit, Polyclonal |
| Artikelnummer: | ASB-ARP60359_P050 |
| Hersteller Artikelnummer: | ARP60359_P050 |
| Alternativnummer: | ASB-ARP60359_P050-25UL,ASB-ARP60359_P050-100UL |
| Hersteller: | Aviva |
| Wirt: | Rabbit |
| Kategorie: | Antikörper |
| Applikation: | WB |
| Spezies Reaktivität: | Bovine, Equine, Human, Porcine, Rat |
| Immunogen: | The immunogen is a synthetic peptide directed towards the C terminal region of human SH2D1A |
| Alternative Synonym: | LYP, SAP, XLP, DSHP, EBVS, IMD5, XLPD, MTCP1, XLPD1, SAP/SH2D1A |
| SH2D1A is a protein that plays a major role in the bidirectional stimulation of T and B cells. It associates with the signaling lymphocyte-activation molecule, thereby acting as an inhibitor of this transmembrane protein by blocking the recruitment of the SH2-domain-containing signal-transduction molecule SHP-2 to its docking site. This protein can also bind to other related surface molecules that are expressed on activated T, B and NK cells, thereby modifying signal transduction pathways in these cells. Mutations in SH2D1A gene cause lymphoproliferative syndrome X-linked type 1 or Duncan disease, a rare immunodeficiency characterized by extreme susceptibility to infection with Epstein-Barr virus, with symptoms including severe mononucleosis and malignant lymphoma. |
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