SH2D1A Antibody - C-terminal region, Rabbit, Polyclonal

Product Overview

• Article Name: SH2D1A Antibody - C-terminal region, Rabbit, Polyclonal
• Biozol Catalog Number: ASB-ARP60359_P050
• Supplier Catalog Number: ARP60359_P050
• Alternative Catalog Number: ASB-ARP60359_P050-25UL,ASB-ARP60359_P050-100UL
• Manufacturer: Aviva
• Host: Rabbit
• Category: Antikörper
• Application: WB
• Species Reactivity: Bovine, Equine, Human, Porcine, Rat
• Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human SH2D1A
• Alternative Names: LYP, SAP, XLP, DSHP, EBVS, IMD5, XLPD, MTCP1, XLPD1, SAP/SH2D1A

Product Description

SH2D1A is a protein that plays a major role in the bidirectional stimulation of T and B cells. It associates with the signaling lymphocyte-activation molecule, thereby acting as an inhibitor of this transmembrane protein by blocking the recruitment of the SH2-domain-containing signal-transduction molecule SHP-2 to its docking site. This protein can also bind to other related surface molecules that are expressed on activated T, B and NK cells, thereby modifying signal transduction pathways in these cells. Mutations in SH2D1A gene cause lymphoproliferative syndrome X-linked type 1 or Duncan disease, a rare immunodeficiency characterized by extreme susceptibility to infection with Epstein-Barr virus, with symptoms including severe mononucleosis and malignant lymphoma.

Product Properties

• Clonality: Polyclonal
• Concentration: 0.5 mg/ml
• Molecular Weight: 14kDa
• NCBI: 4068
• UniProt: O60880
• Form: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.