PSEN2 Antibody - middle region
Artikelnummer:
ASB-ARP97209_P050
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| Artikelname: | PSEN2 Antibody - middle region |
| Artikelnummer: | ASB-ARP97209_P050 |
| Hersteller Artikelnummer: | ARP97209_P050 |
| Alternativnummer: | ASB-ARP97209_P050-25UL,ASB-ARP97209_P050-100UL |
| Hersteller: | Aviva |
| Wirt: | Rabbit |
| Kategorie: | Proteine/Peptide |
| Applikation: | WB |
| Spezies Reaktivität: | Mouse |
| Immunogen: | The immunogen is a synthetic peptide directed towards the middle region of mouse PSEN2 |
| Alternative Synonym: | P, PS, ALG, Ad4, PS2, Ad4h, Alg3, PS-2, STM2, ALG-3, Psnl2 |
| This gene encodes a member of the presenilin family. Presenilins are catalytic components of the multi-subunit gamma-secretase complex, which mediates critical cellular processes through cleavage of type I transmembrane proteins including Notch receptors and the amyloid precursor protein. The encoded protein contains eight transmembrane domains and is localized to the endoplasmic reticulum, where it may play a role in calcium homeostasis. Following assembly of the gamma-secretase complex, the encoded protein is cleaved into N- and C-terminal fragments and the activated complex is released from the endoplasmic reticulum. Inactivation of this gene results in impaired synaptic function in a mouse model for Alzheimers disease. Alternatively spliced transcript variants have been observed for this gene.A |
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