PSEN2 Antibody - middle region

Product Overview

• Article Name: PSEN2 Antibody - middle region
• Biozol Catalog Number: ASB-ARP97209_P050
• Supplier Catalog Number: ARP97209_P050
• Alternative Catalog Number: ASB-ARP97209_P050-25UL,ASB-ARP97209_P050-100UL
• Manufacturer: Aviva
• Host: Rabbit
• Category: Proteine/Peptide
• Application: WB
• Species Reactivity: Mouse
• Immunogen: The immunogen is a synthetic peptide directed towards the middle region of mouse PSEN2
• Alternative Names: P, PS, ALG, Ad4, PS2, Ad4h, Alg3, PS-2, STM2, ALG-3, Psnl2

Product Description

This gene encodes a member of the presenilin family. Presenilins are catalytic components of the multi-subunit gamma-secretase complex, which mediates critical cellular processes through cleavage of type I transmembrane proteins including Notch receptors and the amyloid precursor protein. The encoded protein contains eight transmembrane domains and is localized to the endoplasmic reticulum, where it may play a role in calcium homeostasis. Following assembly of the gamma-secretase complex, the encoded protein is cleaved into N- and C-terminal fragments and the activated complex is released from the endoplasmic reticulum. Inactivation of this gene results in impaired synaptic function in a mouse model for Alzheimers disease. Alternatively spliced transcript variants have been observed for this gene.A

Product Properties

• Clonality: Polyclonal
• Concentration: 0.5 mg/ml
• Molecular Weight: 50 kDa
• NCBI: 19165
• UniProt: Q61144
• Form: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.