CHRNA7 Antibody - N-terminal region

Produktübersicht

• Artikelname: CHRNA7 Antibody - N-terminal region
• Artikelnummer: ASB-AVARP13018_T100
• Hersteller Artikelnummer: AVARP13018_T100
• Alternativnummer: ASB-AVARP13018_T100-25UL,ASB-AVARP13018_T100-100UL
• Hersteller: Aviva
• Wirt: Rabbit
• Kategorie: Proteine/Peptide
• Applikation: WB
• Spezies Reaktivität: Bovine, Human, Mouse, Rat
• Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human CHRNA7
• Alternative Synonym: NACHRA7, CHRNA7-2

Produktbeschreibung

The nicotinic acetylcholine receptors (nAChRs) are members of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. The nAChRs are thought to be hetero-pentamers composed of homologous subunits. The proposed structure for each subunit is a conserved N-terminal extracellular domain followed by three conserved transmembrane domains, a variable cytoplasmic loop, a fourth conserved transmembrane domain, and a short C-terminal extracellular region. The protein encoded by this gene forms a homo-oligomeric channel, displays marked permeability to calcium ions and is a major component of brain nicotinic receptors that are blocked by, and highly sensitive to, alpha-bungarotoxin. Once this receptor binds acetylcholine, it undergoes an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. CHRNA7 is located in a region identified as a major susceptibility locus for juvenile myoclonic epilepsy and a chromosomal location involved in the genetic transmission of schizophrenia. An evolutionarily recent partial duplication event in this region results in a hybrid containing sequence from CHRNA7 and a novel FAM7A gene.

Produkteigenschaften

• Klonalität: Polyclonal
• Konzentration: 1.0 mg/ml
• Molekulargewicht: 56 kDa
• NCBI: 1139
• UniProt: P36544
• Formulierung: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

Bilder

Host: Rabbit
Target Name: CHRNA7
Sample Tissue: Human Jurkat
Antibody Dilution: 1.0ug/ml

WB Suggested Anti-CHRNA7 Antibody Titration: 2.5ug/ml
Positive Control: HepG2 cell lysate

Host: Rabbit
Target Name: CHRNA7
Sample Type: MDA-MB-435S Cell lysates
Antibody Dilution: 1.0ug/ml

Host: Rat
Target Name: CHRNA7
Sample Tissue: Rat Brain
Antibody Dilution: 1ug/ml

25 ug of the indicated Human whole cell extracts was loaded onto a 12% SDS-PAGE gel. 1 ug/mL of the antibody was used in this experiment.

Host: Rabbit
Target Name: CHRNA7
Sample Tissue: Human Jurkat Whole Cell
Antibody Dilution: 1ug/ml

CHRNA7 antibody - N-terminal region (AVARP13018_T100) in Human Jurkat using Western Blot