CHRNA7 Antibody - N-terminal region
Catalog Number:
ASB-AVARP13018_T100
- Images (7)
| Article Name: | CHRNA7 Antibody - N-terminal region |
| Biozol Catalog Number: | ASB-AVARP13018_T100 |
| Supplier Catalog Number: | AVARP13018_T100 |
| Alternative Catalog Number: | ASB-AVARP13018_T100-25UL,ASB-AVARP13018_T100-100UL |
| Manufacturer: | Aviva |
| Host: | Rabbit |
| Category: | Proteine/Peptide |
| Application: | WB |
| Species Reactivity: | Bovine, Human, Mouse, Rat |
| Immunogen: | The immunogen is a synthetic peptide directed towards the N terminal region of human CHRNA7 |
| Alternative Names: | NACHRA7, CHRNA7-2 |
| The nicotinic acetylcholine receptors (nAChRs) are members of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. The nAChRs are thought to be hetero-pentamers composed of homologous subunits. The proposed structure for each subunit is a conserved N-terminal extracellular domain followed by three conserved transmembrane domains, a variable cytoplasmic loop, a fourth conserved transmembrane domain, and a short C-terminal extracellular region. The protein encoded by this gene forms a homo-oligomeric channel, displays marked permeability to calcium ions and is a major component of brain nicotinic receptors that are blocked by, and highly sensitive to, alpha-bungarotoxin. Once this receptor binds acetylcholine, it undergoes an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. CHRNA7 is located in a region identified as a major susceptibility locus for juvenile myoclonic epilepsy and a chromosomal location involved in the genetic transmission of schizophrenia. An evolutionarily recent partial duplication event in this region results in a hybrid containing sequence from CHRNA7 and a novel FAM7A gene. |
|
|
Host: Rabbit Target Name: CHRNA7 Sample Tissue: Human Jurkat Antibody Dilution: 1.0ug/ml |
|
|
WB Suggested Anti-CHRNA7 Antibody Titration: 2.5ug/ml Positive Control: HepG2 cell lysate |
|
|
Host: Rabbit Target Name: CHRNA7 Sample Type: MDA-MB-435S Cell lysates Antibody Dilution: 1.0ug/ml |
|
|
Host: Rat Target Name: CHRNA7 Sample Tissue: Rat Brain Antibody Dilution: 1ug/ml |
|
|
25 ug of the indicated Human whole cell extracts was loaded onto a 12% SDS-PAGE gel. 1 ug/mL of the antibody was used in this experiment. |
|
|
Host: Rabbit Target Name: CHRNA7 Sample Tissue: Human Jurkat Whole Cell Antibody Dilution: 1ug/ml |
|
|
CHRNA7 antibody - N-terminal region (AVARP13018_T100) in Human Jurkat using Western Blot |
Product Guarantee and Expert Support
