Zcchc11 Antibody - C-terminal region
Artikelnummer:
ASB-OAAB18849
- Bilder (0)
| Artikelname: | Zcchc11 Antibody - C-terminal region |
| Artikelnummer: | ASB-OAAB18849 |
| Hersteller Artikelnummer: | OAAB18849 |
| Alternativnummer: | ASB-OAAB18849-400UL |
| Hersteller: | Aviva |
| Wirt: | Rabbit |
| Kategorie: | Proteine/Peptide |
| Applikation: | WB |
| Spezies Reaktivität: | Mouse |
| Immunogen: | This (Mouse) Zcchc11 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 1568-1600 amino acids from the C-terminal region of (Mouse) Zcchc11. |
| Alternative Synonym: | Tent, PPAPD3, Tent3a, Zcchc11, mKIAA0191, 6030404K05Rik, 9230115F04Rik |
| Uridylyltransferase that acts as a suppressor of microRNA (miRNA) biogenesis by specifically mediating the terminal uridylation of some miRNAs. Catalyzes the 3 uridylation of precursor let-7 (pre-let-7), a miRNA precursor. Uridylated pre- let-7 miRNAs fail to be processed by Dicer and undergo degradation. Degradation of pre-let-7 contributes to the maintenance of embryonic stem (ES) cells and is required for ES cells to maintain pluripotency. Does not bind RNA by itself, recruited to pre-let-7 miRNAs via its interaction with LIN28A and LIN28B (By similarity). Also catalyzes the 3 uridylation of miR- 26A, a miRNA that represses IL6 transcript, leading to abrogate IL6 transcript repression and promote cytokine expression. May also suppress Toll-like receptor-induced NF-kappa-B activity via binding to T2BP. Does not play a role in replication-dependent histone mRNA degradation (By similarity). |
Produktgarantie und fachkundiger Support
