Zcchc11 Antibody - C-terminal region
Catalog Number:
ASB-OAAB18849
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| Article Name: | Zcchc11 Antibody - C-terminal region |
| Biozol Catalog Number: | ASB-OAAB18849 |
| Supplier Catalog Number: | OAAB18849 |
| Alternative Catalog Number: | ASB-OAAB18849-400UL |
| Manufacturer: | Aviva |
| Host: | Rabbit |
| Category: | Proteine/Peptide |
| Application: | WB |
| Species Reactivity: | Mouse |
| Immunogen: | This (Mouse) Zcchc11 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 1568-1600 amino acids from the C-terminal region of (Mouse) Zcchc11. |
| Alternative Names: | Tent, PPAPD3, Tent3a, Zcchc11, mKIAA0191, 6030404K05Rik, 9230115F04Rik |
| Uridylyltransferase that acts as a suppressor of microRNA (miRNA) biogenesis by specifically mediating the terminal uridylation of some miRNAs. Catalyzes the 3 uridylation of precursor let-7 (pre-let-7), a miRNA precursor. Uridylated pre- let-7 miRNAs fail to be processed by Dicer and undergo degradation. Degradation of pre-let-7 contributes to the maintenance of embryonic stem (ES) cells and is required for ES cells to maintain pluripotency. Does not bind RNA by itself, recruited to pre-let-7 miRNAs via its interaction with LIN28A and LIN28B (By similarity). Also catalyzes the 3 uridylation of miR- 26A, a miRNA that represses IL6 transcript, leading to abrogate IL6 transcript repression and promote cytokine expression. May also suppress Toll-like receptor-induced NF-kappa-B activity via binding to T2BP. Does not play a role in replication-dependent histone mRNA degradation (By similarity). |
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