CDKN1B Antibody, IgG1, Clone: [3D8], Mouse, Monoclonal

Produktübersicht

• Artikelname: CDKN1B Antibody, IgG1, Clone: [3D8], Mouse, Monoclonal
• Artikelnummer: ASB-OAAD00359
• Hersteller Artikelnummer: OAAD00359
• Alternativnummer: ASB-OAAD00359-0.1ML
• Hersteller: Aviva
• Wirt: Mouse
• Kategorie: Antikörper
• Applikation: WB
• Spezies Reaktivität: Human
• Immunogen: Purified recombinant fragment of human CDKN1B expressed in E. Coli.
• Alternative Synonym: KIP1, MEN4, CDKN4, MEN1B, P27KIP1

Produktbeschreibung

p27 KIP 1 is a cell cycle regulatory mitotic inhibitor of cdk activity. p27 KIP 1 is a candidate tumor suppressor gene, and has been proposed to function as a possible mediator of TGF beta induced G1 arrest. p27 KIP 1 is up regulated in response to antimitogenic stimuli. The increased protein expression of p27 results in cellular arrest by binding to cyclin/Cdk complexes such as cyclin D1/Cdk4. Decreased levels of p27Kip1, mainly due to proteosomal degradation, are found in various epithelial tumors originating from lung, breast, colon, ovary, esophagus, thyroid and prostate.Tissue specificity: Expressed in all tissues tested.
Highest levels in skeletal muscle, lowest in liver and kidney.

Produkteigenschaften

• Klonalität: Monoclonal
• Klon-Bezeichnung: [3D8]
• Molekulargewicht: 22kDa
• Isotyp: IgG1
• NCBI: 1027
• UniProt: P46527