CDKN1B Antibody, IgG1, Clone: [3D8], Mouse, Monoclonal

Product Overview

• Article Name: CDKN1B Antibody, IgG1, Clone: [3D8], Mouse, Monoclonal
• Biozol Catalog Number: ASB-OAAD00359
• Supplier Catalog Number: OAAD00359
• Alternative Catalog Number: ASB-OAAD00359-0.1ML
• Manufacturer: Aviva
• Host: Mouse
• Category: Antikörper
• Application: WB
• Species Reactivity: Human
• Immunogen: Purified recombinant fragment of human CDKN1B expressed in E. Coli.
• Alternative Names: KIP1, MEN4, CDKN4, MEN1B, P27KIP1

Product Description

p27 KIP 1 is a cell cycle regulatory mitotic inhibitor of cdk activity. p27 KIP 1 is a candidate tumor suppressor gene, and has been proposed to function as a possible mediator of TGF beta induced G1 arrest. p27 KIP 1 is up regulated in response to antimitogenic stimuli. The increased protein expression of p27 results in cellular arrest by binding to cyclin/Cdk complexes such as cyclin D1/Cdk4. Decreased levels of p27Kip1, mainly due to proteosomal degradation, are found in various epithelial tumors originating from lung, breast, colon, ovary, esophagus, thyroid and prostate.Tissue specificity: Expressed in all tissues tested.
Highest levels in skeletal muscle, lowest in liver and kidney.

Product Properties

• Clonality: Monoclonal
• Clone Designation: [3D8]
• Molecular Weight: 22kDa
• Isotype: IgG1
• NCBI: 1027
• UniProt: P46527