RICTOR Antibody, IgG1, Clone: [4H5], Mouse, Monoclonal

Produktübersicht

• Artikelname: RICTOR Antibody, IgG1, Clone: [4H5], Mouse, Monoclonal
• Artikelnummer: ASB-OAAD00372
• Hersteller Artikelnummer: OAAD00372
• Alternativnummer: ASB-OAAD00372-0.1ML
• Hersteller: Aviva
• Wirt: Mouse
• Kategorie: Antikörper
• Applikation: WB
• Spezies Reaktivität: Human, Monkey, Mouse
• Immunogen: Purified recombinant fragment of human RICTOR expressed in E. Coli.
• Alternative Synonym: PIA, AVO3, hAVO3

Produktbeschreibung

Cell growth is a fundamental biological process whereby cells accumulate mass and increase in size. The mammalian TOR (mTOR) pathway regulates growth by coordinating energy and nutrient signals with growth factor-derived signals . mTOR is a large protein kinase with two different complexes. One complex contains mTOR, GAA,L and raptor, which is a target of rapamycin.
The other complex, insensitive to rapamycin, includes mTOR, GAA,L, Sin1 and rictor . The mTOR-rictor complex phosphorylates Ser473 of Akt/PKB in vitro . This phosphorylation is essential for full Akt/PKB activation. Furthermore, an siRNA knockdown of rictor inhibits Ser473 phosphorylation in 3T3-L1 adipocytes . This complex has also been shown to phosphorylate the rapamycin-resistant mutants of S6K1, another effector of mTOR .

Produkteigenschaften

• Klonalität: Monoclonal
• Klon-Bezeichnung: [4H5]
• Molekulargewicht: 192kDa
• Isotyp: IgG1
• NCBI: 253260
• UniProt: Q6R327