RICTOR Antibody, IgG1, Clone: [4H5], Mouse, Monoclonal

Product Overview

• Article Name: RICTOR Antibody, IgG1, Clone: [4H5], Mouse, Monoclonal
• Biozol Catalog Number: ASB-OAAD00372
• Supplier Catalog Number: OAAD00372
• Alternative Catalog Number: ASB-OAAD00372-0.1ML
• Manufacturer: Aviva
• Host: Mouse
• Category: Antikörper
• Application: WB
• Species Reactivity: Human, Monkey, Mouse
• Immunogen: Purified recombinant fragment of human RICTOR expressed in E. Coli.
• Alternative Names: PIA, AVO3, hAVO3

Product Description

Cell growth is a fundamental biological process whereby cells accumulate mass and increase in size. The mammalian TOR (mTOR) pathway regulates growth by coordinating energy and nutrient signals with growth factor-derived signals . mTOR is a large protein kinase with two different complexes. One complex contains mTOR, GAA,L and raptor, which is a target of rapamycin.
The other complex, insensitive to rapamycin, includes mTOR, GAA,L, Sin1 and rictor . The mTOR-rictor complex phosphorylates Ser473 of Akt/PKB in vitro . This phosphorylation is essential for full Akt/PKB activation. Furthermore, an siRNA knockdown of rictor inhibits Ser473 phosphorylation in 3T3-L1 adipocytes . This complex has also been shown to phosphorylate the rapamycin-resistant mutants of S6K1, another effector of mTOR .

Product Properties

• Clonality: Monoclonal
• Clone Designation: [4H5]
• Molecular Weight: 192kDa
• Isotype: IgG1
• NCBI: 253260
• UniProt: Q6R327