UBE1L Antibody, IgG1, Clone: [5B10], Mouse, Monoclonal

Produktübersicht

• Artikelname: UBE1L Antibody, IgG1, Clone: [5B10], Mouse, Monoclonal
• Artikelnummer: ASB-OAAD00373
• Hersteller Artikelnummer: OAAD00373
• Alternativnummer: ASB-OAAD00373-0.1ML
• Hersteller: Aviva
• Wirt: Mouse
• Kategorie: Antikörper
• Applikation: WB
• Spezies Reaktivität: Human
• Immunogen: Purified recombinant fragment of human UBE1L expressed in E. Coli.
• Alternative Synonym: D8, UBE2, UBA1B, UBE1L

Produktbeschreibung

The modification of proteins with ubiquitin is an important cellular mechanism for targeting.Tissue specificity: Expressed in a variety of normal and tumor cell types, but is reduced in lung cancer cell lines abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E1 ubiquitin-activating enzyme family.
The encoded enzyme is a retinoid target that triggers promyelocytic leukemia (PML)/retinoic acid receptor alpha (RARalpha) degradation and apoptosis in acute promyelocytic leukemia, where it is involved in the conjugation of the ubiquitin-like interferon-stimulated gene 15 protein.

Produkteigenschaften

• Klonalität: Monoclonal
• Klon-Bezeichnung: [5B10]
• Molekulargewicht: 112kDa
• Isotyp: IgG1
• NCBI: 7318
• UniProt: P41226