UBE1L Antibody, IgG1, Clone: [5B10], Mouse, Monoclonal

Product Overview

• Article Name: UBE1L Antibody, IgG1, Clone: [5B10], Mouse, Monoclonal
• Biozol Catalog Number: ASB-OAAD00373
• Supplier Catalog Number: OAAD00373
• Alternative Catalog Number: ASB-OAAD00373-0.1ML
• Manufacturer: Aviva
• Host: Mouse
• Category: Antikörper
• Application: WB
• Species Reactivity: Human
• Immunogen: Purified recombinant fragment of human UBE1L expressed in E. Coli.
• Alternative Names: D8, UBE2, UBA1B, UBE1L

Product Description

The modification of proteins with ubiquitin is an important cellular mechanism for targeting.Tissue specificity: Expressed in a variety of normal and tumor cell types, but is reduced in lung cancer cell lines abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E1 ubiquitin-activating enzyme family.
The encoded enzyme is a retinoid target that triggers promyelocytic leukemia (PML)/retinoic acid receptor alpha (RARalpha) degradation and apoptosis in acute promyelocytic leukemia, where it is involved in the conjugation of the ubiquitin-like interferon-stimulated gene 15 protein.

Product Properties

• Clonality: Monoclonal
• Clone Designation: [5B10]
• Molecular Weight: 112kDa
• Isotype: IgG1
• NCBI: 7318
• UniProt: P41226