CDH1 Antibody, IgG1, Clone: [7H12], Mouse, Monoclonal

Produktübersicht

• Artikelname: CDH1 Antibody, IgG1, Clone: [7H12], Mouse, Monoclonal
• Artikelnummer: ASB-OAAD00383
• Hersteller Artikelnummer: OAAD00383
• Alternativnummer: ASB-OAAD00383-0.1ML
• Hersteller: Aviva
• Wirt: Mouse
• Kategorie: Antikörper
• Applikation: FC, IHC, WB
• Spezies Reaktivität: Human, Monkey, Mouse
• Immunogen: Purified recombinant fragment of human CDH1 expressed in E. Coli.
• Alternative Synonym: UVO, CDHE, ECAD, LCAM, Arc-1, BCDS1, CD324

Produktbeschreibung

E-Cadherin is a 120 kDa transmembrane glycoprotein that is localized in the adherens junctions of epithelial cells.
There, it interacts with the cytoskeleton through the associated cytoplasmic catenin proteins. In addition to being a calcium-dependent adhesion molecule, E-Cadherin is also a critical regulator of epithelial junction formation. Its association with catenins is necessary for cell-cell adhesion. These E-cadherin/catenin complexes associate with corical actin bundles at both the zonula adherens and the lateral adhesion plaques. Tyrosine phosphorylation can disrupt these complexes, leading to changes in cell adhesion properties. E-Cadherin expression is often down-regulated in highly invasive, poorly differentiated carcinomas. Increased expression of E-Cadherin in these cells reduces invasiveness. Thus, loss of expression or function of E-Cadherin appears to be an important step in tumorigenic progression.Tissue specificity: Non-neural epithelial tissues.

Produkteigenschaften

• Klonalität: Monoclonal
• Klon-Bezeichnung: [7H12]
• Molekulargewicht: 135kDa
• Isotyp: IgG1
• NCBI: 999
• UniProt: P12830