CDH1 Antibody, IgG1, Clone: [7H12], Mouse, Monoclonal
Catalog Number:
ASB-OAAD00383
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| Article Name: | CDH1 Antibody, IgG1, Clone: [7H12], Mouse, Monoclonal |
| Biozol Catalog Number: | ASB-OAAD00383 |
| Supplier Catalog Number: | OAAD00383 |
| Alternative Catalog Number: | ASB-OAAD00383-0.1ML |
| Manufacturer: | Aviva |
| Host: | Mouse |
| Category: | Antikörper |
| Application: | FC, IHC, WB |
| Species Reactivity: | Human, Monkey, Mouse |
| Immunogen: | Purified recombinant fragment of human CDH1 expressed in E. Coli. |
| Alternative Names: | UVO, CDHE, ECAD, LCAM, Arc-1, BCDS1, CD324 |
| E-Cadherin is a 120 kDa transmembrane glycoprotein that is localized in the adherens junctions of epithelial cells. There, it interacts with the cytoskeleton through the associated cytoplasmic catenin proteins. In addition to being a calcium-dependent adhesion molecule, E-Cadherin is also a critical regulator of epithelial junction formation. Its association with catenins is necessary for cell-cell adhesion. These E-cadherin/catenin complexes associate with corical actin bundles at both the zonula adherens and the lateral adhesion plaques. Tyrosine phosphorylation can disrupt these complexes, leading to changes in cell adhesion properties. E-Cadherin expression is often down-regulated in highly invasive, poorly differentiated carcinomas. Increased expression of E-Cadherin in these cells reduces invasiveness. Thus, loss of expression or function of E-Cadherin appears to be an important step in tumorigenic progression.Tissue specificity: Non-neural epithelial tissues. |
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