late endosomal/lysosomal adaptor and MAPK and MTOR activator 3,MAP2K1IP1,MAPBP,MAPK scaffold protein 1,MAPKSP1,MEK binding partner 1,MEK-binding partner 1,mitogen-activated protein kinase kinase 1 interacting protein 1,Mitogen-activated protein kinase kinase 1-interacting protein 1,mitogen-activated protein kinase scaffold protein 1,MP1,PRO0633,ragulator complex protein LAMTOR3,Ragulator3.
As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. Adapter protein that enhances the efficiency of the MAP kinase cascade facilitating the activation of MAPK2.
If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.
