MECA-79(MECA-79), 0.2mg/mL, Clone: [MECA-79], Rat, Monoclonal
Artikelnummer:
BOT-BNUB1599-100
Hersteller Artikelnummer:
BNUB1599-100
Alternativnummer:
BOT-BNUB1599-100-100UL
Hersteller:
Biotium
Wirt:
Rat
Kategorie:
Antikörper
Applikation:
ELISA, FC, Functional Studies, IF, IHC
Spezies Reaktivität:
Human, Mouse, Rat
Immunogen:
Mouse lymph node stromal cells
Alternative Synonym:
MECA-79, Peripheral Node Addressin (PNAd)
MECA-79 recognizes a carbohydrate epitope shared with a group of sulfation decorated sialomucins, including sulfated ligands for CD62L (CD34, GlyCAM-1, Sgp200, and a subset of MAdCAM-1). This set of antigens has been referred to as peripheral node addressin (PNAd) with the molecular mass 50-250 kD. It has been identified that GlcNAc-6-SO4 sulfation contributes to MECA-79 binding and the core 1 beta1, 3-N-acetylglucosaminyltransferase is required for the generation of the MECA-79 epitope. MECA-79 is expressed on high endothelial venules (HEV) of lymphoid tissues, chronic inflamed tissues and rheumatoid synovia. The interaction of PNAd with CD62L receptor is involved in tethering and rolling of lymphocytes along HEV in lymphoid tissues. MECA-79 antibody reacts with PNAd from mouse, human and many other species and blocks L-selectin-dependent lymphocyte adhesion in vitro and in vivo. Primary antibodies are available purified, or with a selection of fluorescent CF Dyes and other labels. CF Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF405S and CF405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
Klonalität:
Monoclonal
Konzentration:
0.2 mg/mL
Klon-Bezeichnung:
[MECA-79]
Molekulargewicht:
90-110 kDa
UniProt:
Not Known
Puffer:
PBS, 0.05% BSA, 0.05% azide
Quelle:
Animal
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten
