MECA-79(MECA-79), 0.2mg/mL, Clone: [MECA-79], Rat, Monoclonal
Biozol Catalog Number:
BOT-BNUB1599-100
Supplier Catalog Number:
BNUB1599-100
Alternative Catalog Number:
BOT-BNUB1599-100-100UL
Manufacturer:
Biotium
Host:
Rat
Category:
Antikörper
Application:
ELISA, FC, Functional Studies, IF, IHC
Species Reactivity:
Human, Mouse, Rat
Immunogen:
Mouse lymph node stromal cells
Alternative Names:
MECA-79, Peripheral Node Addressin (PNAd)
MECA-79 recognizes a carbohydrate epitope shared with a group of sulfation decorated sialomucins, including sulfated ligands for CD62L (CD34, GlyCAM-1, Sgp200, and a subset of MAdCAM-1). This set of antigens has been referred to as peripheral node addressin (PNAd) with the molecular mass 50-250 kD. It has been identified that GlcNAc-6-SO4 sulfation contributes to MECA-79 binding and the core 1 beta1, 3-N-acetylglucosaminyltransferase is required for the generation of the MECA-79 epitope. MECA-79 is expressed on high endothelial venules (HEV) of lymphoid tissues, chronic inflamed tissues and rheumatoid synovia. The interaction of PNAd with CD62L receptor is involved in tethering and rolling of lymphocytes along HEV in lymphoid tissues. MECA-79 antibody reacts with PNAd from mouse, human and many other species and blocks L-selectin-dependent lymphocyte adhesion in vitro and in vivo. Primary antibodies are available purified, or with a selection of fluorescent CF Dyes and other labels. CF Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF405S and CF405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
Clonality:
Monoclonal
Concentration:
0.2 mg/mL
Clone Designation:
[MECA-79]
Molecular Weight:
90-110 kDa
UniProt:
Not Known
Buffer:
PBS, 0.05% BSA, 0.05% azide
Source:
Animal
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