CDKN1A/p21 Polyclonal Antibody, Biotin Conjugated, Rabbit

Produktübersicht

• Artikelname: CDKN1A/p21 Polyclonal Antibody, Biotin Conjugated, Rabbit
• Artikelnummer: BSS-BS-0741R-BIOTIN
• Hersteller Artikelnummer: bs-0741R-Biotin
• Alternativnummer: BSS-BS-0741R-BIOTIN-100
• Hersteller: Bioss
• Wirt: Rabbit
• Kategorie: Antikörper
• Applikation: ELISA, IHC-Fr, IHC-P, WB
• Spezies Reaktivität: Human, Mouse, Rat
• Konjugation: Biotin
• Alternative Synonym: P21, CDKI, CIP1, SDI1, Waf1, mda6, CAP2, Cdkn1, p21WAF, p21Cip1, Cyclin-dependent kinase inhibitor 1, CDK-interacting protein 1, Melanoma differentiation-associated protein, Cdkn1a

Produktbeschreibung

May be the important intermediate by which p53/TP53 mediates its role as an inhibitor of cellular proliferation in response to DNA damage. Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression. Functions in the nuclear localization and assembly of cyclin D-CDK4 complex and promotes its kinase activity towards RB1. At higher stoichiometric ratios, inhibits the kinase activity of the cyclin D-CDK4 complex (By similarity).

Produkteigenschaften

• Klonalität: Polyclonal
• Konzentration: 1ug/ul
• NCBI: 12575
• UniProt: P38936
• Puffer: Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
• Quelle: KLH conjugated synthetic peptide derived from human CDKN1A
• Target-Kategorie: CDKN1A/p21

Anwendungsbeschreibung

• Application Verdünnung: WB(1:300-5000), ELISA(1:500-1000), IHC-P(1:200-400), IHC-F(1:100-500)